P189Vascular ageing is apparent during an oral glucose challenge in healthy humans
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چکیده
منابع مشابه
Metabolite Profiles During Oral Glucose Challenge
To identify distinct biological pathways of glucose metabolism, we conducted a systematic evaluation of biochemical changes after an oral glucose tolerance test (OGTT) in a community-based population. Metabolic profiling was performed on 377 nondiabetic Framingham Offspring cohort participants (mean age 57 years, 42% women, BMI 30 kg/m(2)) before and after OGTT. Changes in metabolite levels wer...
متن کاملTetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects.
An oral glucose challenge causes transient impairment of endothelial function, probably because of increased oxidative stress. During oxidative stress, endothelial nitric oxide (NO) synthase (eNOS) becomes uncoupled because of decreased bioavailability of tetrahydrobiopterin (BH4), an essential cofactor of eNOS. Therefore, we examined whether an acute supplement of BH4 could restore endothelial...
متن کاملAnaphylaxis to Celebrex during an oral challenge
Case We report a case of a 65-year-old female with an anaphylactic type reaction during a graded oral celecoxib challenge. She was previously using NSAIDS and Celebrex (celecoxib) for analgesia in 2005. However, due to the side effect profile of COX2 inhibitors, Celebrex was discontinued. The patient’s primary analgesic was ibuprofen. Upon reintroduction of Celebrex, the patient developed urtic...
متن کاملWhen is an oral food challenge positive?
Oral food challenges still remain the gold standard in the diagnosis of food related symptoms and are performed to obtain a clear 'yes or no' response. However, this is often difficult to achieve, and so proposals may be appropriate for criteria on when to stop oral food challenges. In daily practice it makes sense to challenge until clear objective symptoms occur without harming the patient. C...
متن کاملOne-Hour Glucose During an Oral Glucose Challenge Prospectively Predicts β-Cell Deterioration and Prediabetes in Obese Hispanic Youth
OBJECTIVE In adults, 1-h glucose during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes independent of fasting and 2-h glucose concentrations. The purpose of the current investigation was to examine the utility of elevated 1-h glucose levels to prospectively predict deterioration in β-cell function and the development of prediabetes in high-risk youth. RESEAR...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2014
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvu082.124